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ENANTIOSELECTIVE SYNTHESIS OF AN ANTICANCER RUTHENIUM POLYPYRIDYL COMPLEX (RPC) AND INFLUENCE OF CHIRAL SELECTIVITY ON DNA PHOTOCLEAVAGE
(2017-12-08)
Ruthenium polypyridyl complexes (RPCs) represent a promising therapeiutic class of drugs for transition-metal based anticancer drug development. The complex [(phen)2Ru(tatpp)Ru(phen)2] (44+) is a RPC which has shown success ...
Supercharging and Multiple Reaction Monitoring Optimization of High Molecular Weight Intact Proteins using Triple Quadrupole Mass Spectrometry
(2019-07-17)
Various supercharging agents, such as meta-nitrobenzyl alcohol, dimethyl sulfoxide, trifluoroethanol (TFE), and sulfolane were tested in different concentrations to study the effects of supercharging agents on the charge ...
3,5-Bis(3,5-bis(trifluoromethyl)phenyl)pyrazolyl complexes of Coinage Metals
(2018-05-16)
Pyrazoles are an important class of five membered heterocyclic compounds consisting of two nitrogen atoms. Pyrazolate anions serve as useful ligands in coordination chemistry. When fluorinated substituents are attached to ...
STUDIES ON ENANTIOSELECTIVE DESYMMETRIZING ALKYNE HYDROSILYLATION
(2021-08-12)
This research focuses on the design and synthesis of enantioselective desymmetrizing α-hydrosilylation of propargyl alcohols to provide α-hydroxy (E)-vinylsilanes. Transition metal-catalyzed, regio-and stereoselective ...
Chemically Modified Cyclofructans for Sub/supercritical Fluid Chromatography and Hydrophilic Interaction Liquid Chromatography
(2022-08-16)
Given the importance of supercritical fluid chromatography, several works focused on the application use different SFC stationary phases. In this work, two new derivatized cyclofructan bonded phases with superficially ...
A Continuously Renewed Copper Electrode for Constant-Potential Amperometry
(2022-12-09)
Pulsed amperometric detection (PAD) is a well-established technique used for the detection of electroactive compounds following Ion Chromatography (IC). Target analytes, such as carbohydrates and amino acids, typically ...
LnCrTeO6 (Ln= La, Pr, Nd) octahedral distortions and optical characterization
(2022-08-17)
LnCrTeO6 (La, Pr, Nd) compounds are suspected to appear as vibrant blue-green colored materials. LnCrTeO6 (La, Pr, Nd) were synthesized to analyze the local coordination environments of Ln3+, Cr3+, and Te6+ cations. ...
Probing Inter-Subunit Communication of F₄₂₀ NADP Oxidoreductase: A Kinetic Analysis
(2019-05-20)
F₄₂₀-dependent enzymes are important in a number of organisms, which play vital roles in methane production, NADPH regulation, nucleic acid biosynthesis, folate biosynthesis and carbon cycling. Until our recent publications ...
The Effects of the Stereochemistry of Ruthenium (II) Polypyridyl Complexes on Microtubules as Targets for Chemotherapy
(2019-05-16)
Ruthenium polypyridyl complexes (RPCs) are promising anticancer agents due to their robustness and tunability of their polypyridyl ligands. Their axial chirality generally allows for more selective binding to biological ...
Synthesis of modified polydiacetylene (PDA) polymers for the detection of infective species
(2019-08-09)
Polydiacetylene (PDAs) polymers are receiving more attention as biosensors due to their ability to change absorption and fluorescence properties upon sensing various chemical and physical changes in the environment. In ...