Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 81-100 of 173
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Leveraging propargylic frameworks in the total synthesis of natural products containing a 2-aminoimidazole
(2019-08-30)Our group is mainly interested in the total synthesis of marine sponge-derived 2-aminoimidazole-containing alkaloids. A new family of 2-aminoimidazole alkaloids, the Leucetta alkaloids, is a group of >60, 2-aminoimidazole ... -
LIQUID FLOW MEASUREMENT: FROM INLINE HYDROCEPHALUS SHUNT FLOW MONITOR TO FLOWMETRY IN THE NANOLITER/MINUTE SCALE
(2019-08-13)This dissertation primarily focuses on designing and developing novel sensing strategies and instruments for ultra-low liquid flow measurement. An inline thermal flow sensor based on a single common thermistor has been ... -
Long non-coding RNAs in inflammation, macrophage activation, and inflammatory human diseases
(2023-08-28)**Please note that the full text is embargoed until 08/01/2025** Inflammation and immune signaling is central to infection and diseases. Growing evidence suggests that along with protein coding genes, long non-coding RNAs ... -
Mass Spectrometry-based Biomolecular Recognition And Response Factor Investigations Using Electrospray Ionization
(Chemistry & Biochemistry, 2008-09-17)Integrins are transmembrane proteins found in almost all cells. They play vital roles in many biological processes, such as angiogenesis and signal transduction, through their interactions with different extracellular ... -
MECHANISM AND USE OF PAIRED ION ELECTROSPRAY IONIZATION (PIESI) IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (HPLC-MS) FOR SENSITIVE ANALYSIS OF ANIONIC COMPOUNDS
(2016-04-18)In recent years, the paired ion electrospray ionization (PIESI) technique has been emerged as a promising alternative to overcome the inherent low sensitivity of negative ESI-MS. The current research focused on the further ... -
Mechanistic And Kinetic Studies On F420H2: NADP+ Oxidoreductase From Archeoglobus fulgidus
F420H2: NADP+ Oxidoreductase (Fno) is an F420 cofactor dependent enzyme that catalyzes the reversible reduction of NADP+ to NADPH by transferring a hydride from the reduced F420 cofactor. F420 cofactor is an essential ... -
MECHANISTIC STUDIES OF F420-DEPENDENT ENZYMES BY KINETIC ANALYSIS
(2021-08-10)The focus of this research is to elucidate the catalytic mechanism of F420-dependent enzymes using F420-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacteria tuberculosis (Mtb) and F420H2:NADP+ Oxidoreductase ... -
Mechanistic Study Of Cysteine Dioxygenase, A Non-heme Mononuclear Iron Enzyme
(Chemistry & Biochemistry, 2014-09-17)Cysteine dioxygenase (CDO) is an non-heme mononuclear iron enzymes that catalyzes the O2-dependent oxidation of L-cysteine (Cys) to produce cysteine sulfinic acid (CSA). CDO controls cysteine levels in cells and is a ... -
MECHANISTIC STUDY OF THE INHIBITION OF RHO GTPASE-MEDIATED METASTASIS
(2019-01-04)The Ras superfamily of small GTPases are monomeric proteins that bind guanine nucleotides, and regulate many cellular signaling pathways. They function as molecular switches by shuttling between active GTP-bound and inactive ... -
Mixed Lineage Leukemia Histone Methylases In Gene Expresion And Cancer
(Chemistry & Biochemistry, 2009-09-16)Histone methyl-transferases (HMTs) are key enzymes that post-translationally methylate nuclear histone proteins and play critical roles in gene expression, epigenetic regulation and diseases in eukaryotic organisms. Mixed ... -
Mixed Lineage Leukemia Histone Methylases In Hormonal Regulation Of HOX Genes And Their Disruption By Endocrine Disrupting Chemicals
(Chemistry & Biochemistry, 2014-03-10)Homeobox (HOX) genes are highly conserved family of genes that play vital roles during cell differentiation and embryogenesis. Of the 39 HOX genes present in human, HOXC6 is a critical players in mammary gland development, ... -
Mixed Lineage Luekemia Histone Methyltransferases In Hormonal Regulation Of HOXB9 And Target Gene Regulation
(Chemistry & Biochemistry, 2014-09-17)Homeobox gene (HOX) genes are evolutionary conserved genes that play important roles in cell differentiation, cell proliferation and embryogenesis. HOX genes bind to the DNA via their homeodomain and act as transcription ... -
Modeling ETR1 with Isolable Coinage Metal Complexes Supported by Partially Fluorinated, and Methylated Scorpionates
Ethylene is a small molecule that functions as a plant hormone that is closely associated with several vital plant functions ranging from germination, shoot and root growth, sex expression, fruit ripening, senescence and ... -
Molecular dynamics simulations of the adenylate kinase enzyme and its mutant states
(2022-12-19)Adenylate kinase (AK) is a small, monomeric enzyme present across all domains of life. It is responsible for maintaining homeostasis of an intracellular adenylate pool and catalyzes a reversible transfer of the phosphoryl ... -
Multinuclear copper(I) and silver(I) pyrazolates: synthesis, luminescence, and catalysis
(2021-12-08)Copper and silver pyrazolate complexes have numerous fascinating properties such as luminescence, catalytic ability, and complexation with small molecules. Using both more widely studied non-fluorinated pyrazolates and ... -
Nanopore Stochastic Sensing With Ionic Liquid Supporting Electrolyte And Ionic Liquid Based Water Quantitation Using Gas Chromatography
(Chemistry & Biochemistry, 2011-03-03)This dissertation focuses toward finding two new avenues to explore the properties of ionic liquids (ILs). First, ILs has been used as a novel, and advantageous supporting electrolytes in nanopore stochastic sensing ... -
New Applications Of The Pauson-Khand Reaction And Studies Towards The Synthesis Of The Hamigerans
(Chemistry & Biochemistry, 2007-09-17)This dissertation is divided into two parts. The first part describes the dicobalt octacarbonyl mediated synthesis of medium sized rings via intramolecular Pauson-Khand (IMPK) reaction. The cyclization of 1,8-enynes has ... -
New Bonded Phase Materials For Separtions
(Chemistry & Biochemistry, 2013-03-20)Separations play an important role in day to day life as well as in science and technology. This dissertation focuses on novel and versatile techniques involving synthesizing new bonded chiral stationary phases (CSPs) and ... -
NEW FLEXIBLE MOLDABLE ION-EXCHANGE POLYMERS AND THEIR ANALYTICAL APPLICATIONS
(2021-08-03)This dissertation aims to improve the functionality of open tubular capillary ion chromatography (OTIC) in terms of the lower limit of detection (LOD) and higher sensitivity by fabricating a microchannel suppressor and ... -
New GC Separation Approaches And Analysis Of Antioxidants From Rosemary (Rosmarinus officinalis L.) And Their Stabilities By HPLC
(Chemistry & Biochemistry, 2012-04-11)Enantiomeric separations are of great interest in the pharmaceutical, biotechnology and agrochemical industries due to the different therapeutic effects of enantiomers. Because of the high efficiency, sensitivity and ...