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Novel Functions And Physiological Significance Of Ral Interacting Protein - RLIP76 In In Vitro And In Vivo Models
(Chemistry & Biochemistry, 2007-08-23)
This dissertation is divided into four parts. The first part is an introduction of energy dependent xenobiotic transporters and their relevance in multidrug resistance. However, the main focuse is the description of RLIP76 ...
Development And Application Of New Mass Spectrometry-based Proteomics Technologies To Post-translational Modifications
(Chemistry & Biochemistry, 2009-09-16)
Post-translational modifications (PTMs) represent one of the major cellular mechanisms to diversify the limited number of proteins coded by genome. They provide dynamic regulation of protein functions and the means to ...
Mixed Lineage Leukemia Histone Methylases In Gene Expresion And Cancer
(Chemistry & Biochemistry, 2009-09-16)
Histone methyl-transferases (HMTs) are key enzymes that post-translationally methylate nuclear histone proteins and play critical roles in gene expression, epigenetic regulation and diseases in eukaryotic organisms. Mixed ...
Cytotoxicity Studies On Metallo-salens And Their Applications In Gene Delivery
(Chemistry & Biochemistry, 2009-09-16)
Most of biological catalysts including nucleases are made of active metal centers. Metal complexes that are able to interact with DNA and RNA mimicking these natural nucleases will be valuable as therapeutic agents that ...
Synthesis And Study Of Fluorinated Thiophenes, Bithiophenes And Trithiophenes: Models For The Polymeric Material
(Chemistry & Biochemistry, 2009-09-16)
3-Fluorothiophene is a small molecule and the known syntheses for this molecule are far from being straight forward and suffer from many drawbacks such as low yield, long synthetic procedures and the use of expensive or ...
Investigation Of Ruthenium (II) Polypyridyl Dimers As Potential Chemotherapeutic Agents
(Chemistry & Biochemistry, 2007-08-23)
The exploration of transition metal complexes as chemotherapeutic agents is still a relatively unexplored but promising area of research. Chapter 1 highlights the most successful anticancer drugs and potential drugs based ...
Investigation Of Redox-active Ruthenium(II) Polypyridyl Complexes As Potential Anti-cancer Drugs
(Chemistry & Biochemistry, 2009-09-16)
Stereospecific binding of ruthenium metallointercalators with DNA is of particular interest because of the potential for improved targeting of specific sites in DNA. The present studies are focused on new metallointercalator, ...
Assemblies Of Assemblies: Supramolecular Ordering Of Nanoscopic Ruthenium Polypyridyl Building Blocks
(Chemistry & Biochemistry, 2008-04-22)
Biological systems have long since perfected the development of
nanoengineering. Cellular structure and machinery is based, to a significant extent, on
the formation of nanometer to micron-sized assemblies of proteins. ...
Mass Spectrometry-based Biomolecular Recognition And Response Factor Investigations Using Electrospray Ionization
(Chemistry & Biochemistry, 2008-09-17)
Integrins are transmembrane proteins found in almost all cells. They play vital roles in many biological processes, such as angiogenesis and signal transduction, through their interactions with different extracellular ...
Plasma Surface Modifications For Biomedical And Electrical Applications
(Chemistry & Biochemistry, 2009-09-16)
The focus of this work centers on molecular structuring of surfaces. The surface modifications were achieved using plasma polymerization technology, specifically variable duty cycle pulsed plasmas. The results obtained ...