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Ral Interacting Protein (Ralbp1): Linking Glutathione Conjugate Transport To Oxidative Stress Defenses And Signaling Pathways
(Chemistry & Biochemistry, 2008-08-08)
The glutathione-conjugate transporter protein DNP-SG ATPase was demonstrated to be identical to the independently cloned Ral-effector, Ralbp1. Glutathione-conjugate transport is linked to substrate-stimulated ATPase activity, ...
Calix[4]arene-based Synthetic Nanotubes
(Chemistry & Biochemistry, 2007-08-23)
Nanoscale science and technology represents a tremendous opportunity to gain unprecedented insight into the unique phenomena that exists at the nanometer scale, and to use that knowledge to develop materials and devices ...
Synthetic Studies And Biological Evaluation Of Imidazole-containing Marine Alkaloids
(Chemistry & Biochemistry, 2008-08-08)
This dissertation discusses the synthetic methods towards and the preliminary biological studies of an unnamed, imidazole-containing alkaloid, derived from the marine species Oceanapia. This alkaloid was first discovered ...
Oligomeric And Polymeric Bibenzimidazole Based Metal Complexes And Crosslinked Polyethylenimine Based Flame Retardants
(Chemistry & Biochemistry, 2007-08-23)
In Part I, a simple and mild condensation route for the synthesis of novel bibenzimidazole oligomers and polymers is described using methyl 2,2,2-trichloroacetimidate as a key starting material. The dimer, trimer, tetramer, ...
Ralbp1 In Stress Resistance
(Chemistry & Biochemistry, 2008-08-08)
Ralbp1 is a multi-specific transporter of glutathione conjugates as well as unconjugated amphiphilic toxins. Because glutathione conjugates are major metabolites of toxic lipid peroxidation products generated as a consequence ...
Novel Functions And Physiological Significance Of Ral Interacting Protein - RLIP76 In In Vitro And In Vivo Models
(Chemistry & Biochemistry, 2007-08-23)
This dissertation is divided into four parts. The first part is an introduction of energy dependent xenobiotic transporters and their relevance in multidrug resistance. However, the main focuse is the description of RLIP76 ...
Development And Application Of New Mass Spectrometry-based Proteomics Technologies To Post-translational Modifications
(Chemistry & Biochemistry, 2009-09-16)
Post-translational modifications (PTMs) represent one of the major cellular mechanisms to diversify the limited number of proteins coded by genome. They provide dynamic regulation of protein functions and the means to ...
Mixed Lineage Leukemia Histone Methylases In Gene Expresion And Cancer
(Chemistry & Biochemistry, 2009-09-16)
Histone methyl-transferases (HMTs) are key enzymes that post-translationally methylate nuclear histone proteins and play critical roles in gene expression, epigenetic regulation and diseases in eukaryotic organisms. Mixed ...
Slowing DNA Translocation In A Biological Protein α-hemolysin Ion Channel
(Chemistry & Biochemistry, 2011-07-14)
During the past decade, nanopore DNA sequencing has emerged as a revolutionary prospect towards a "$1000 genome" goal set by U.S. National Institute of Health. In the nanopore approach, electrophoretic movement of ...
Cytotoxicity Studies On Metallo-salens And Their Applications In Gene Delivery
(Chemistry & Biochemistry, 2009-09-16)
Most of biological catalysts including nucleases are made of active metal centers. Metal complexes that are able to interact with DNA and RNA mimicking these natural nucleases will be valuable as therapeutic agents that ...