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Novel Animal Model And In Vivo Imaging System To Study Inflammatory Response-mediated Cancer Metastasis
(Biomedical Engineering, 2010-07-19)
Cancer metastasis is the leading cause of death in cancer patients. A vast majority of cancer-related mortality is attributed to this rather than the primary tumor itself, making the understanding of cancer metastasis ...
Novel Applications Of Compressed Sensing To Magnetic Resonance Imaging And Spectroscopy
(Biomedical Engineering, 2012-04-11)
In this work, three novel applications of compressed sensing to MRI have been developed and implemented which accomplish reduction in acquisition time, thereby also enabling increased spatial and/or temporal resolution. ...
A Novel Minimally Invasive Dual-modality Fiber Optic Probe For Prostate Cancer Detection
(Biomedical Engineering, 2013-03-20)
Prostate cancer is the most common form of cancer in males, and is the second leading cause of cancer related deaths in United States. In prostate cancer diagnostics and theapy, there is a critical need for a minimally ...
Novel ¹H MR Probes To Interrogate The Tumor Microenvironment
(Biomedical Engineering, 2011-10-11)
The term "tumor microenvironment" usually refers to the description of the physiological and metabolic conditions within solid tumors (primary or metastatic), and is significantly different from that of normal tissues. ...
Wireless Closed-loop Feedback Systems For Automatic Detection And Suppression Of Nociceptive Signals
(Biomedical Engineering, 2011-10-11)
Chronic pain is an important public health issue. Several approaches have been implemented for management of chronic pain, including surgical implantation of neurostimulators. Neurostimulators have been used in clinics for ...
Methodology Of Citrate-based Biomaterial Development And Application
(Biomedical Engineering, 2012-04-11)
Biomaterials play central roles in modern strategies of regenerative medicine and tissue engineering. Attempts to find tissue-engineered solutions to cure various injuries or diseases have led to an enormous increase in ...
Advances In Helical Stent Design And Fabrication: Studies Of Stent Thermal Treatment, Stent Mechanical Properties, And Stent Interactions With A Simulated Plaque-laden Artery
(Biomedical Engineering, 2010-11-01)
Advancements in processing biomaterials have lead to the development of bioresorbable PLLA drug-loaded stents with different geometric configurations. To further advance the technology, systematic studies have been carried ...
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-frontal Cortex Using Functional Near Infra-red Spectroscopy
(Biomedical Engineering, 2011-10-11)
Perception of pain is multi-dimensional, comprising three major psychological dimensions: sensory-discriminative, motivational-affective and cognitive-evaluative. This dissertation study investigates the cognitive evaluation ...
Application Of Scanning Correlation Spectroscopy Techniques To Quantify DNA Double Strand Break Repair Kinetics In The Living Cell After Exposure To γ-rays And Radiomimetic Chemicals
(Biomedical Engineering, 2013-03-20)
The kinetics of most proteins involved in DNA damage sensing, signaling and repair following ionizing radiation exposure cannot be quantified by current live cell fluorescence microscopy methods. This is because most of ...
Phase Sensitive Spectral Domain Interferometry For Label Free Biomolecular Interaction Analysis And Biosensing Applications
(Biomedical Engineering, 2013-03-20)
Biomolecular interaction analysis (BIA) plays vital role in wide variety of fields, which include biomedical research, pharmaceutical industry, medical diagnostics, and biotechnology industry. Study and quantification of ...