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Now showing items 51-60 of 60
Development Of Orchestrated Stem Cell-based Regeneration (OSCeR) -strategies To Recruit And Differentiate Autologous Stem Cells For Tissue Regeneration
(Biomedical Engineering, 2011-03-03)
Stem cell therapy has shown great promise in curing diseases. However, clinical application of stem cell therapy is often hindered by the lack of reliable sources and convenient methods to recover stem cells. Our laboratory ...
UNDERSTANDING KEY GENETIC MUTATIONS AND MOLECULAR ALTERATIONS ON INCREASING MIGRATION, VIABILITY, DRUG RESISTANCE OF MALIGNANT BRAIN TUMOR IN CONFINEMENT
(2017-08-10)
There are more than 120 types of primary brain and central nervous system tumors that affect people of all ages. Glioblastoma multiforme (GBM), for example, is the most frequent type of brain cancers and also among the ...
Creep Response and Adhesion Dynamics of Glioblastoma Multiforme Cells During Migration in Confined Environment
(2018-05-10)
Glioblastoma multiforme (GBM) is the most common and malignant form of primary brain tumor. One of the major challenges facing the treatment of GBM tumors is the detachment and subsequent migration of peripheral cells. ...
CENTIMETER-DEEP TISSUE FLUORESCENCE MICROSCOPIC IMAGING
(2016-07-26)
Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information—such as microcirculation, tumor angiogenesis, and cancer metastasis—may ...
Targeted Delivery Of Carbon Nanotubes To Cancer Cells
(Biomedical Engineering, 2010-07-19)
CD22 is broadly expressed on human B cell lymphomas. Monoclonal anti-CD22 antibodies (MAbs) alone, or coupled to toxins, have been used to selectively target these tumors both in severe combined immunodeficient (SCID) mice ...
Enhanced Endothelialization On Surface Modified Poly(L-lactic Acid)
(Biomedical Engineering, 2010-07-19)
Current synthetic vascular grafts and polymer-coated drug-eluting stents (DES) have certain limitations, such as thrombosis and restenosis due to the incomplete recovery of vascular endothelial cells on their luminal sides. ...
Mechanisms Of Biomaterial Mediated Fibrotic Responses And Strategies To Improve Tissue Reactions To Biomaterial Implants
(Biomedical Engineering, 2010-07-19)
Despite considerable advancements in biomaterial synthesis and modification techniques, most tissue engineering scaffolds elicit fibrotic reactions resulting in implant encapsulation, secluding cells and/or therapeutic ...
DEVELOPMENT OF AN IN VITRO TBI MODELS AND VALIDATION OF NANODELIVERY FOR RESTORATION OF DISRUPTED BRAIN ENDOTHELIUM
(2019-09-06)
Blast-induced traumatic brain injury (bTBI) is a serious concern among military personnel and their families. Although the mechanisms responsible for disruption to the brain are not well understood, the development of ...
DEVELOPMENT AND INVESTIGATION OF FLUORESCENCE IMAGING PROBES
(2019-09-03)
Fluorescence imaging has attracted much attention due to high sensitivity, spatial and temporal resolution, and fast acquisition time, for imaging biomolecular processes and for diagnosis of diseases such as cancer in early ...
Establishing The Method Of Dual-tensor For Tract Based Analysis (DTTA) And Investigating Human Brain Developmental Connectome With Diffusion MRI
(Biomedical Engineering, 2014-07-14)
Diffusion MRI (dMRI) has the unique ability of studying white matter fiber structure in the human brain in-vivo. The trajectory of the white matter fibers inside the brain can be mapped using the tractography techniques ...